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Structure paper

TitleThe structure of human GCN2 reveals a parallel, back-to-back kinase dimer with a plastic DFG activation loop motif.
Journal, issue, pagesBiochem. J., Vol. 477, Page 275-284, Year 2020
Publish dateJan 6, 2022 (structure data deposition date)
AuthorsMaia de Oliveira, T. / Korboukh, V. / Caswell, S. / Winter Holt, J.J. / Lamb, M. / Hird, A.W. / Overman, R.
External linksBiochem. J. / PubMed:31868900
MethodsX-ray diffraction
Resolution2.3 - 2.8 Å
Structure data

PDB-7qq6:
GCN2 (EIF2ALPHA KINASE 4, E2AK4) IN COMPLEX WITH COMPOUND 1 (dovitinib)
Method: X-RAY DIFFRACTION / Resolution: 2.8 Å

PDB-7qwk:
GCN2 (EIF2ALPHA KINASE 4, E2AK4) IN COMPLEX WITH COMPOUND 2
Method: X-RAY DIFFRACTION / Resolution: 2.3 Å

Chemicals

ChemComp-38O:
4-amino-5-fluoro-3-[5-(4-methylpiperazin-1-yl)-1H-benzimidazol-2-yl]quinolin-2(1H)-one

ChemComp-HOH:
WATER

ChemComp-G41:
(2~{S})-~{N}-[(1~{S})-1-[4-[(6-pyridin-4-ylquinazolin-2-yl)amino]phenyl]ethyl]piperidine-2-carboxamide

ChemComp-DMS:
DIMETHYL SULFOXIDE / DMSO, precipitant*YM

Source
  • homo sapiens (human)
KeywordsTRANSFERASE / EIF2 kinase / Integrated Stress Response / GCN2 / ISR

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