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TitleTeixobactin kills bacteria by a two-pronged attack on the cell envelope.
Journal, issue, pagesNature, Vol. 608, Page 390-396, Year 2022
Publish dateDec 10, 2021 (structure data deposition date)
AuthorsShukla, R. / Lavore, F. / Maity, S. / Derks, M.G.N. / Jones, C.R. / Vermeulen, B.J.A. / Melcrova, A. / Morris, M.A. / Becker, L.M. / Wang, X. ...Shukla, R. / Lavore, F. / Maity, S. / Derks, M.G.N. / Jones, C.R. / Vermeulen, B.J.A. / Melcrova, A. / Morris, M.A. / Becker, L.M. / Wang, X. / Kumar, R. / Medeiros-Silva, J. / van Beekveld, R.A.M. / Bonvin, A.M.J.J. / Lorent, J.H. / Lelli, M. / Nowick, J.S. / MacGillavry, H.D. / Peoples, A.J. / Spoering, A.L. / Ling, L.L. / Hughes, D.E. / Roos, W.H. / Breukink, E. / Lewis, K. / Weingarth, M.
External linksNature / PubMed:35922513
MethodsNMR (solid-state)
Structure data

PDB-7qgv:
Solid-state NMR structure of Teixobactin-Lipid II.
Method: SOLID-STATE NMR

Chemicals

ChemComp-2PO:
PHOSPHONATE

ChemComp-P1W:
3-methylbut-2-en-1-ol

Source
  • eleftheria terrae (bacteria)
  • staphylococcus aureus (bacteria)
KeywordsANTIBIOTIC / antimicrobial / beta-sheet / membrane deformation

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