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-Structure paper
Title | Highly potent inhibitors of cathepsin K with a differently positioned cyanohydrazide warhead: structural analysis of binding mode to mature and zymogen-like enzymes. |
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Journal, issue, pages | J Enzyme Inhib Med Chem, Vol. 37, Page 515-526, Year 2022 |
Publish date | Nov 19, 2021 (structure data deposition date) |
![]() | Benysek, J. / Busa, M. / Rubesova, P. / Fanfrlik, J. / Lepsik, M. / Brynda, J. / Matouskova, Z. / Bartz, U. / Horn, M. / Gutschow, M. / Mares, M. |
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Methods | X-ray diffraction |
Resolution | 1.55 - 2 Å |
Structure data | ![]() PDB-7qbl: ![]() PDB-7qbm: ![]() PDB-7qbn: ![]() PDB-7qbo: |
Chemicals | ![]() ChemComp-A0U: ![]() ChemComp-HOH: ![]() ChemComp-ACT: ![]() ChemComp-MG: ![]() ChemComp-9ZG: ![]() ChemComp-CL: ![]() ChemComp-EDO: |
Source |
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![]() | HYDROLASE / Cathepsin K / Protease inhibitor / Cyanohydrazide warhead / Azadipeptide nitrile |