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TitleSynthesis of thieno[2,3-c]pyridine derived GRK2 inhibitors
Journal, issue, pagesMonatsh Chem, Year 2022
Publish dateOct 6, 2021 (structure data deposition date)
AuthorsBalo, T. / Sapi, A. / Kiss, A. / Raimbaud, E. / Paysant, J. / Cattin, M.E. / Berger, S. / Kotschy, A. / Faucher, N.
External linksMonatsh Chem / Search PubMed
MethodsX-ray diffraction
Resolution2.6 Å
Structure data

PDB-7pwd:
Structure of an inhibited GRK2-G-beta and G-gamma complex
Method: X-RAY DIFFRACTION / Resolution: 2.6 Å

Chemicals

ChemComp-8DS:
4-chloranyl-N-[2-(4-chlorophenyl)ethyl]thieno[2,3-c]pyridine-2-carboxamide

ChemComp-CL:
Unknown entry

ChemComp-1PE:
PENTAETHYLENE GLYCOL / precipitant*YM

ChemComp-GOL:
GLYCEROL

ChemComp-HOH:
WATER

Source
  • homo sapiens (human)
  • bos taurus (domestic cattle)
KeywordsTRANSFERASE / Proteros / GRK2 / Inhibition / Heart failure / Kinase

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