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Structure paper

TitleThe zinc-binding motif in tankyrases is required for the structural integrity of the catalytic ADP-ribosyltransferase domain.
Journal, issue, pagesOpen Biology, Vol. 12, Page 210365-210365, Year 2022
Publish dateSep 10, 2021 (structure data deposition date)
AuthorsSowa, S.T. / Lehtio, L.
External linksOpen Biology / PubMed:35317661
MethodsX-ray diffraction
Resolution2.5 Å
Structure data

PDB-7pox:
TNKS2 in complex with OM-1700, treated with H2O2
Method: X-RAY DIFFRACTION / Resolution: 2.5 Å

Chemicals

ChemComp-N8K:
~{N}-[3-[5-(5-ethoxypyridin-2-yl)-4-(2-fluorophenyl)-1,2,4-triazol-3-yl]cyclobutyl]pyridine-2-carboxamide

ChemComp-HOH:
WATER

Source
  • homo sapiens (human)
KeywordsTRANSFERASE / Zinc / coordination / enzyme / poly-adp-ribosylation / inhibitor / h2o2

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