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Structure paper

TitleHedgehog-Interacting Protein is a multimodal antagonist of Hedgehog signalling.
Journal, issue, pagesNat Commun, Vol. 12, Page 7171-7171, Year 2021
Publish dateAug 14, 2021 (structure data deposition date)
AuthorsGriffiths, S.C. / Schwab, R.A. / El Omari, K. / Bishop, B. / Iverson, E.J. / Malinauskas, T. / Dubey, R. / Qian, M. / Covey, D.F. / Gilbert, R.J.C. ...Griffiths, S.C. / Schwab, R.A. / El Omari, K. / Bishop, B. / Iverson, E.J. / Malinauskas, T. / Dubey, R. / Qian, M. / Covey, D.F. / Gilbert, R.J.C. / Rohatgi, R. / Siebold, C.
External linksNat Commun / PubMed:34887403
MethodsX-ray diffraction
Resolution2.4 - 2.75 Å
Structure data

PDB-7pgk:
HHIP-N, the N-terminal domain of the Hedgehog-Interacting Protein (HHIP), in complex with glycosaminoglycan mimic SOS
Method: X-RAY DIFFRACTION / Resolution: 2.75 Å

PDB-7pgl:
HHIP-N, the N-terminal domain of the Hedgehog-Interacting Protein (HHIP), apo-form
Method: X-RAY DIFFRACTION / Resolution: 2.63 Å

PDB-7pgm:
HHIP-C in complex with heparin
Method: X-RAY DIFFRACTION / Resolution: 2.7 Å

PDB-7pgn:
HHP-C in complex with glycosaminoglycan mimic SOS
Method: X-RAY DIFFRACTION / Resolution: 2.4 Å

Chemicals

ChemComp-CA:
Unknown entry

ChemComp-GOL:
GLYCEROL

ChemComp-HOH:
WATER

Source
  • homo sapiens (human)
KeywordsSIGNALING PROTEIN / HHIP / Hedgehog / morphogen / signalling / glycosaminoglycan / cholesterol / palmitate / secreted

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