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Structure paper

TitleStructural basis for long-chain isoprenoid synthesis by cis -prenyltransferases.
Journal, issue, pagesSci Adv, Vol. 8, Page eabn1171-eabn1171, Year 2022
Publish dateJul 30, 2021 (structure data deposition date)
AuthorsGiladi, M. / Lisnyansky Bar-El, M. / Vankova, P. / Ferofontov, A. / Melvin, E. / Alkaderi, S. / Kavan, D. / Redko, B. / Haimov, E. / Wiener, R. ...Giladi, M. / Lisnyansky Bar-El, M. / Vankova, P. / Ferofontov, A. / Melvin, E. / Alkaderi, S. / Kavan, D. / Redko, B. / Haimov, E. / Wiener, R. / Man, P. / Haitin, Y.
External linksSci Adv / PubMed:35584224
MethodsX-ray diffraction
Resolution2 - 2.59 Å
Structure data

PDB-7pax:
Structure of the human heterotetrameric cis-prenyltransferase complex in complex with magnesium, FsPP and IPP
Method: X-RAY DIFFRACTION / Resolution: 2 Å

PDB-7pay:
Structure of the human heterotetrameric cis-prenyltransferase complex in complex with magnesium and GGsPP
Method: X-RAY DIFFRACTION / Resolution: 2.4 Å

PDB-7pb0:
Structure of the human heterotetrameric cis-prenyltransferase complex in complex with magnesium, GGsPP and IsPP
Method: X-RAY DIFFRACTION / Resolution: 2.301 Å

PDB-7pb1:
Structure of the human heterotetrameric cis-prenyltransferase complex in complex with magnesium, GGPP and IsPP
Method: X-RAY DIFFRACTION / Resolution: 2.59 Å

Chemicals

ChemComp-IPE:
3-METHYLBUT-3-ENYL TRIHYDROGEN DIPHOSPHATE

ChemComp-FPS:
S-[(2E,6E)-3,7,11-TRIMETHYLDODECA-2,6,10-TRIENYL] TRIHYDROGEN THIODIPHOSPHATE

ChemComp-MG:
Unknown entry

ChemComp-HOH:
WATER

ChemComp-SO4:
SULFATE ION

ChemComp-GGS:
phosphonooxy-[(10E)-3,7,11,15-tetramethylhexadeca-2,6,10,14-tetraenyl]sulfanyl-phosphinic acid

ChemComp-ISY:
3-methylbut-3-enylsulfanyl(phosphonooxy)phosphinic acid

ChemComp-GRG:
GERANYLGERANYL DIPHOSPHATE

Source
  • homo sapiens (human)
KeywordsTRANSFERASE / DHDDS / NgBR / hcit / cis-prenyltransferase / dolichol

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