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-Structure paper
Title | Synthesis, structure-activity relationships, cocrystallization and cellular characterization of novel smHDAC8 inhibitors for the treatment of schistosomiasis. |
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Journal, issue, pages | Eur. J. Med. Chem., Vol. 225, Page 113745-113745, Year 2021 |
Publish date | Jul 8, 2021 (structure data deposition date) |
![]() | Ghazy, E. / Heimburg, T. / Lancelot, J. / Zeyen, P. / Schmidtkunz, K. / Truhn, A. / Darwish, S. / Simoben, C.V. / Shaik, T.B. / Erdmann, F. ...Ghazy, E. / Heimburg, T. / Lancelot, J. / Zeyen, P. / Schmidtkunz, K. / Truhn, A. / Darwish, S. / Simoben, C.V. / Shaik, T.B. / Erdmann, F. / Schmidt, M. / Robaa, D. / Romier, C. / Jung, M. / Pierce, R. / Sippl, W. |
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Methods | X-ray diffraction |
Resolution | 1.546 Å |
Structure data | ![]() PDB-7p3s: |
Chemicals | ![]() ChemComp-ZN: ![]() ChemComp-K: ![]() ChemComp-GOL: ![]() ChemComp-5IB: ![]() ChemComp-HOH: |
Source |
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![]() | HYDROLASE / Epigenetics / Histone deacetylase / HDAC8 / Selective inhibitor / Pathogen |