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TitleIdentification of Pyrimidine-Based Lead Compounds for Understudied Kinases Implicated in Driving Neurodegeneration.
Journal, issue, pagesJ. Med. Chem., Vol. 65, Page 1313-1328, Year 2022
Publish dateJul 1, 2021 (structure data deposition date)
AuthorsDrewry, D.H. / Annor-Gyamfi, J.K. / Wells, C.I. / Pickett, J.E. / Dederer, V. / Preuss, F. / Mathea, S. / Axtman, A.D.
External linksJ. Med. Chem. / PubMed:34333981
MethodsX-ray diffraction
Resolution1.95 Å
Structure data

PDB-7p1l:
The MARK3 Kinase Domain Bound To AA-CS-1-008
Method: X-RAY DIFFRACTION / Resolution: 1.95 Å

Chemicals

ChemComp-V5E:
5-Bromo-4-N-[2-(1H-imidazol-5-yl)ethyl]-2-N-[3-(morpholin-4-ylmethyl)phenyl]pyrimidine-2,4-diamine

ChemComp-EDO:
1,2-ETHANEDIOL

ChemComp-HOH:
WATER

Source
  • homo sapiens (human)
KeywordsTRANSFERASE / Kinase Inhibitor Active site Folded activation loop UBA domain

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