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-Structure paper
Title | ARN25068, a versatile starting point towards triple GSK-3 beta /FYN/DYRK1A inhibitors to tackle tau-related neurological disorders. |
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Journal, issue, pages | Eur. J. Med. Chem., Vol. 229, Page 114054-114054, Year 2022 |
Publish date | Jun 23, 2021 (structure data deposition date) |
![]() | Demuro, S. / Sauvey, C. / Tripathi, S.K. / Di Martino, R.M.C. / Shi, D. / Ortega, J.A. / Russo, D. / Balboni, B. / Giabbai, B. / Storici, P. ...Demuro, S. / Sauvey, C. / Tripathi, S.K. / Di Martino, R.M.C. / Shi, D. / Ortega, J.A. / Russo, D. / Balboni, B. / Giabbai, B. / Storici, P. / Girotto, S. / Abagyan, R. / Cavalli, A. |
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Methods | X-ray diffraction |
Resolution | 2.38 - 2.57 Å |
Structure data | ![]() PDB-7oy5: ![]() PDB-7oy6: |
Chemicals | ![]() ChemComp-39I: ![]() ChemComp-CL: ![]() ChemComp-HOH: |
Source |
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![]() | TRANSFERASE / Inhibitor / complex / GSK-3B |