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Title | Discovery of Novel Inhibitors of Uridine Diphosphate- N -Acetylenolpyruvylglucosamine Reductase (MurB) from Pseudomonas aeruginosa , an Opportunistic Infectious Agent Causing Death in Cystic Fibrosis Patients. |
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Journal, issue, pages | J. Med. Chem., Vol. 65, Page 2149-2173, Year 2022 |
Publish date | Jun 4, 2021 (structure data deposition date) |
![]() | Acebron-Garcia-de-Eulate, M. / Mayol-Llinas, J. / Holland, M.T.O. / Kim, S.Y. / Brown, K.P. / Marchetti, C. / Hess, J. / Di Pietro, O. / Mendes, V. / Abell, C. ...Acebron-Garcia-de-Eulate, M. / Mayol-Llinas, J. / Holland, M.T.O. / Kim, S.Y. / Brown, K.P. / Marchetti, C. / Hess, J. / Di Pietro, O. / Mendes, V. / Abell, C. / Floto, R.A. / Coyne, A.G. / Blundell, T.L. |
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Methods | X-ray diffraction |
Resolution | 1.85 - 2.35 Å |
Structure data | ![]() PDB-7or2: ![]() PDB-7orz: ![]() PDB-7osq: |
Chemicals | ![]() ChemComp-FAD: ![]() ChemComp-9FH: ![]() ChemComp-HOH: ![]() ChemComp-0IM: ![]() ChemComp-GOL: ![]() ChemComp-0JI: |
Source |
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![]() | OXIDOREDUCTASE / Peptidoglycan-biosynthesis Fragment based drug discovery / Peptidoglycan-biosynthesis / Fragment based drug discovery |