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Structure paper

TitleAn LNA-amide modification that enhances the cell uptake and activity of phosphorothioate exon-skipping oligonucleotides.
Journal, issue, pagesNat Commun, Vol. 13, Page 4036-4036, Year 2022
Publish dateMar 4, 2021 (structure data deposition date)
AuthorsBaker, Y.R. / Thorpe, C. / Chen, J. / Poller, L.M. / Cox, L. / Kumar, P. / Lim, W.F. / Lie, L. / McClorey, G. / Epple, S. ...Baker, Y.R. / Thorpe, C. / Chen, J. / Poller, L.M. / Cox, L. / Kumar, P. / Lim, W.F. / Lie, L. / McClorey, G. / Epple, S. / Singleton, D. / McDonough, M.A. / Hardwick, J.S. / Christensen, K.E. / Wood, M.J.A. / Hall, J.P. / El-Sagheer, A.H. / Brown, T.
External linksNat Commun / PubMed:35821218
MethodsX-ray diffraction
Resolution2.57 - 2.7 Å
Structure data

PDB-7nrp:
The crystal structure of a DNA:RNA hybrid duplex sequence CTTTTCTTTG
Method: X-RAY DIFFRACTION / Resolution: 2.67 Å

PDB-7ooo:
The crystal structure of a DNA:RNA hybrid duplex sequence CTTTTCTTTG containing an LNA-Amide-LNA modification
Method: X-RAY DIFFRACTION / Resolution: 2.57 Å

PDB-7oos:
The crystal structure of a DNA:RNA hybrid duplex sequence CTTTTCTTTG
Method: X-RAY DIFFRACTION / Resolution: 2.6 Å

PDB-7ozz:
The crystal structure of a DNA:RNA hybrid duplex sequence CTTTTCTTTG with LNA-amide modification
Method: X-RAY DIFFRACTION / Resolution: 2.7 Å

Chemicals

ChemComp-CAC:
CACODYLATE ION

ChemComp-HOH:
WATER

ChemComp-MG:
Unknown entry

ChemComp-SR:
STRONTIUM ION

ChemComp-K:
Unknown entry

Source
  • synthetic construct (others)
KeywordsDNA-RNA HYBRID / Amide-LNA / duplex / DNA:RNA / unmodified / DNA:RNA HYBRID

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