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-Structure paper
Title | Discovery of AZD8154, a Dual PI3K gamma delta Inhibitor for the Treatment of Asthma. |
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Journal, issue, pages | J. Med. Chem., Vol. 64, Page 8053-8075, Year 2021 |
Publish date | May 11, 2021 (structure data deposition date) |
Authors | Perry, M.W.D. / Bjorhall, K. / Bold, P. / Brulls, M. / Borjesson, U. / Carlsson, J. / Chang, H.A. / Chen, Y. / Eriksson, A. / Fihn, B.M. ...Perry, M.W.D. / Bjorhall, K. / Bold, P. / Brulls, M. / Borjesson, U. / Carlsson, J. / Chang, H.A. / Chen, Y. / Eriksson, A. / Fihn, B.M. / Fransson, R. / Fredlund, L. / Ge, H. / Huang, H. / Karabelas, K. / Lamm Bergstrom, E. / Lever, S. / Lindmark, H. / Mogemark, M. / Nikitidis, A. / Palmgren, A.P. / Pemberton, N. / Petersen, J. / Rodrigo Blomqvist, M. / Smith, R.W. / Thomas, M.J. / Ullah, V. / Tyrchan, C. / Wennberg, T. / Westin Eriksson, A. / Yang, W. / Zhao, S. / Oster, L. |
External links | J. Med. Chem. / PubMed:34080862 |
Methods | X-ray diffraction |
Resolution | 1.8 - 2.3 Å |
Structure data | PDB-7oi4: PDB-7oij: PDB-7oil: PDB-7ois: |
Chemicals | ChemComp-VEQ: ChemComp-HOH: ChemComp-VEH: ChemComp-NA: ChemComp-PGE: ChemComp-VEN: ChemComp-VEW: |
Source |
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Keywords | TRANSFERASE / Inhibitor / complex / phosphor inositol 3 kinase / mPI3kd |