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Title | Fragment-based Scaffold Hopping: Identification of Potent, Selective, and Highly Soluble Bromo and Extra Terminal Domain (BET) Second Bromodomain (BD2) Inhibitors. |
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Journal, issue, pages | J. Med. Chem., Vol. 64, Page 10772-10805, Year 2021 |
Publish date | May 1, 2021 (structure data deposition date) |
Authors | Seal, J.T. / Atkinson, S.J. / Bamborough, P. / Bassil, A. / Chung, C.W. / Foley, J. / Gordon, L. / Grandi, P. / Gray, J.R.J. / Harrison, L.A. ...Seal, J.T. / Atkinson, S.J. / Bamborough, P. / Bassil, A. / Chung, C.W. / Foley, J. / Gordon, L. / Grandi, P. / Gray, J.R.J. / Harrison, L.A. / Kruger, R.G. / Matteo, J.J. / McCabe, M.T. / Messenger, C. / Mitchell, D. / Phillipou, A. / Preston, A. / Prinjha, R.K. / Rianjongdee, F. / Rioja, I. / Taylor, S. / Wall, I.D. / Watson, R.J. / Woolven, J.M. / Wyce, A. / Zhang, X.P. / Demont, E.H. |
External links | J. Med. Chem. / PubMed:34255512 |
Methods | X-ray diffraction |
Resolution | 1.602 - 1.762 Å |
Structure data | PDB-7oe4: PDB-7oe5: PDB-7oe6: PDB-7ogy: |
Chemicals | ChemComp-EDO: ChemComp-PE4: ChemComp-V9B: ChemComp-HOH: ChemComp-V9H: ChemComp-V9K: ChemComp-VE5: ChemComp-PEG: |
Source |
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Keywords | NUCLEAR PROTEIN / Inhibitor / bromodomain |