+Search query
-Structure paper
Title | Optimization of a Screening Hit toward M2912, an Oral Tankyrase Inhibitor with Antitumor Activity in Colorectal Cancer Models. |
---|---|
Journal, issue, pages | J. Med. Chem., Vol. 64, Page 10371-10392, Year 2021 |
Publish date | Apr 28, 2021 (structure data deposition date) |
Authors | Buchstaller, H.P. / Anlauf, U. / Dorsch, D. / Kogler, S. / Kuhn, D. / Lehmann, M. / Leuthner, B. / Lodholz, S. / Musil, D. / Radtki, D. ...Buchstaller, H.P. / Anlauf, U. / Dorsch, D. / Kogler, S. / Kuhn, D. / Lehmann, M. / Leuthner, B. / Lodholz, S. / Musil, D. / Radtki, D. / Rettig, C. / Ritzert, C. / Rohdich, F. / Schneider, R. / Wegener, A. / Weigt, S. / Wilkinson, K. / Esdar, C. |
External links | J. Med. Chem. / PubMed:34255518 |
Methods | X-ray diffraction |
Resolution | 1.432 Å |
Structure data | PDB-7ocv: |
Chemicals | ChemComp-ACT: ChemComp-V8B: ChemComp-ZN: ChemComp-HOH: |
Source |
|
Keywords | TRANSFERASE / TANKYRASE / PARP / INHIBITOR / TRANSFERASE-TRANSFERASE INHIBITOR |