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-Structure paper
Title | The development of highly potent and selective small molecule correctors of Z alpha 1 -antitrypsin misfolding. |
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Journal, issue, pages | Bioorg. Med. Chem. Lett., Vol. 41, Page 127973-127973, Year 2021 |
Publish date | Feb 27, 2021 (structure data deposition date) |
Authors | Liddle, J. / Pearce, A.C. / Arico-Muendel, C. / Belyanskaya, S. / Brewster, A. / Brown, M. / Chung, C.W. / Denis, A. / Dodic, N. / Dossang, A. ...Liddle, J. / Pearce, A.C. / Arico-Muendel, C. / Belyanskaya, S. / Brewster, A. / Brown, M. / Chung, C.W. / Denis, A. / Dodic, N. / Dossang, A. / Eddershaw, P. / Klimaszewska, D. / Haq, I. / Holmes, D.S. / Jagger, A. / Jakhria, T. / Jigorel, E. / Lind, K. / Messer, J. / Neu, M. / Olszewski, A. / Ronzoni, R. / Rowedder, J. / Rudiger, M. / Skinner, S. / Smith, K.J. / Trottet, L. / Uings, I. / Zhu, Z. / Irving, J.A. / Lomas, D.A. |
External links | Bioorg. Med. Chem. Lett. / PubMed:33753261 |
Methods | X-ray diffraction |
Resolution | 1.82 - 1.83 Å |
Structure data | PDB-7npk: PDB-7npl: |
Chemicals | ChemComp-GOL: ChemComp-UL2: ChemComp-HOH: ChemComp-UKZ: |
Source |
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Keywords | UNKNOWN FUNCTION / apha1 antitrypsin (C232S) / SERPRIN / INHIBITOR / COMPLEX / SERPIN |