+Search query
-Structure paper
Title | Mechanisms of the Antiproliferative and Antitumor Activity of Novel Telomerase-Carbonic Anhydrase Dual-Hybrid Inhibitors. |
---|---|
Journal, issue, pages | J. Med. Chem., Vol. 64, Page 11432-11444, Year 2021 |
Publish date | Apr 16, 2020 (structure data deposition date) |
![]() | Plyasova, A.A. / Berrino, E. / Khan, I.I. / Veselovsky, A.V. / Pokrovsky, V.S. / Angeli, A. / Ferraroni, M. / Supuran, C.T. / Pokrovskaya, M.V. / Alexandrova, S.S. ...Plyasova, A.A. / Berrino, E. / Khan, I.I. / Veselovsky, A.V. / Pokrovsky, V.S. / Angeli, A. / Ferraroni, M. / Supuran, C.T. / Pokrovskaya, M.V. / Alexandrova, S.S. / Gladilina, Y.A. / Sokolov, N.N. / Hilal, A. / Carta, F. / Zhdanov, D.D. |
![]() | ![]() ![]() |
Methods | X-ray diffraction |
Resolution | 1.1 - 1.28 Å |
Structure data | ![]() PDB-6ypw: ![]() PDB-7nh6: |
Chemicals | ![]() ChemComp-ZN: ![]() ChemComp-P75: ![]() ChemComp-HOH: ![]() ChemComp-GOL: ![]() ChemComp-UDE: |
Source |
|
![]() | LYASE / Carbonic Anhydrase Inhibitors; AZT; Telomerase Inhibitors; Cancer; Molecular hybrids; Click Chemistry; Triazole. / carbonic anhydrase II / inhibitor / metalloenzyme / sulfonamide |