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-Structure paper
Title | Design and synthesis of aryl-piperidine derivatives as potent and selective PET tracers for cholesterol 24-hydroxylase (CH24H) |
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Journal, issue, pages | Eur. J. Med. Chem., Vol. 240, Page 114612-, Year 2022 |
Publish date | Jun 8, 2021 (structure data deposition date) |
![]() | Ikeda, S. / Kajita, Y. / Miyamoto, M. / Matsumiya, K. / Ishii, T. / Nishi, T. / Gay, S.C. / Lane, W. / Constantinescu, C.C. / Alagille, D. ...Ikeda, S. / Kajita, Y. / Miyamoto, M. / Matsumiya, K. / Ishii, T. / Nishi, T. / Gay, S.C. / Lane, W. / Constantinescu, C.C. / Alagille, D. / Papin, C. / Tamagnan, G. / Kuroita, T. / Koike, T. |
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Methods | X-ray diffraction |
Resolution | 1.4 Å |
Structure data | ![]() PDB-7n6f: |
Chemicals | ![]() ChemComp-HEM: ![]() ChemComp-0I1: ![]() ChemComp-EDO: ![]() ChemComp-GOL: ![]() ChemComp-HOH: |
Source |
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![]() | OXIDOREDUCTASE / cyp46a1 / ch24h / sbdd / drug discovery |