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-Structure paper
Title | Discovery and Early Clinical Development of LY3202626, a Low-Dose, CNS-Penetrant BACE Inhibitor. |
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Journal, issue, pages | J. Med. Chem., Vol. 64, Page 8076-8100, Year 2021 |
Publish date | May 21, 2021 (structure data deposition date) |
Authors | McKinzie, D.L. / Winneroski, L.L. / Green, S.J. / Hembre, E.J. / Erickson, J.A. / Willis, B.A. / Monk, S.A. / Aluise, C.D. / Baker, T.K. / Lopez, J.E. ...McKinzie, D.L. / Winneroski, L.L. / Green, S.J. / Hembre, E.J. / Erickson, J.A. / Willis, B.A. / Monk, S.A. / Aluise, C.D. / Baker, T.K. / Lopez, J.E. / Hendle, J. / Beck, J.P. / Brier, R.A. / Boggs, L.N. / Borders, A.R. / Cocke, P.J. / Garcia-Losada, P. / Lowe, S.L. / Mathes, B.M. / May, P.C. / Porter, W.J. / Stout, S.L. / Timm, D.E. / Watson, B.M. / Yang, Z. / Mergott, D.J. |
External links | J. Med. Chem. / PubMed:34081466 |
Methods | X-ray diffraction |
Resolution | 1.25 - 1.94 Å |
Structure data | PDB-7myi: PDB-7myr: PDB-7myu: |
Chemicals | ChemComp-ZQS: ChemComp-GOL: ChemComp-HOH: ChemComp-ZRD: ChemComp-SO4: ChemComp-ZR7: |
Source |
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Keywords | HYDROLASE/HYDROLASE INHIBITOR / protease / HYDROLASE-HYDROLASE INHIBITOR complex / HYDROLASE |