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-Structure paper
Title | Imaging active site chemistry and protonation states: NMR crystallography of the tryptophan synthase alpha-aminoacrylate intermediate. |
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Journal, issue, pages | Proc. Natl. Acad. Sci. USA, Vol. 119, Year 2022 |
Publish date | May 12, 2021 (structure data deposition date) |
![]() | Holmes, J.B. / Liu, V. / Caulkins, B.G. / Hilario, E. / Ghosh, R.K. / Drago, V.N. / Young, R.P. / Romero, J.A. / Gill, A.D. / Bogie, P.M. ...Holmes, J.B. / Liu, V. / Caulkins, B.G. / Hilario, E. / Ghosh, R.K. / Drago, V.N. / Young, R.P. / Romero, J.A. / Gill, A.D. / Bogie, P.M. / Paulino, J. / Wang, X. / Riviere, G. / Bosken, Y.K. / Struppe, J. / Hassan, A. / Guidoulianov, J. / Perrone, B. / Mentink-Vigier, F. / Chang, C.A. / Long, J.R. / Hooley, R.J. / Mueser, T.C. / Dunn, M.F. / Mueller, L.J. |
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Methods | X-ray diffraction |
Resolution | 1.4 - 1.7 Å |
Structure data | ![]() PDB-7mt4: ![]() PDB-7mt5: ![]() PDB-7mt6: |
Chemicals | ![]() ChemComp-F9F: ![]() ChemComp-0JO: ![]() ChemComp-NH4: ![]() ChemComp-HOH: ![]() ChemComp-CS: ![]() ChemComp-BZI: |
Source |
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![]() | LYASE/INHIBITOR / PLP-dependent enzyme Tryptophan synthase / LYASE / LYASE-INHIBITOR complex |