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-Structure paper
Title | Discovery of EEDi-5273 as an Exceptionally Potent and Orally Efficacious EED Inhibitor Capable of Achieving Complete and Persistent Tumor Regression. |
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Journal, issue, pages | J. Med. Chem., Vol. 64, Page 14540-14556, Year 2021 |
Publish date | May 11, 2021 (structure data deposition date) |
Authors | Rej, R.K. / Wang, C. / Lu, J. / Wang, M. / Petrunak, E. / Zawacki, K.P. / McEachern, D. / Yang, C.Y. / Wang, L. / Li, R. ...Rej, R.K. / Wang, C. / Lu, J. / Wang, M. / Petrunak, E. / Zawacki, K.P. / McEachern, D. / Yang, C.Y. / Wang, L. / Li, R. / Chinnaswamy, K. / Wen, B. / Sun, D. / Stuckey, J.A. / Zhou, Y. / Chen, J. / Tang, G. / Wang, S. |
External links | J. Med. Chem. / PubMed:34613724 |
Methods | X-ray diffraction |
Resolution | 1.9 - 2.2 Å |
Structure data | PDB-7msb: PDB-7msd: |
Chemicals | ChemComp-ZNG: ChemComp-HOH: ChemComp-ZMY: ChemComp-FMT: |
Source |
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Keywords | GENE REGULATION/INHIBITOR / polycomb repressive complex 2 / GENE REGULATION-INHIBITOR complex |