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-Structure paper
Title | 4-Methyl-1,2,3-Triazoles as N -Acetyl-Lysine Mimics Afford Potent BET Bromodomain Inhibitors with Improved Selectivity. |
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Journal, issue, pages | J. Med. Chem., Vol. 64, Page 10497-10511, Year 2021 |
Publish date | Apr 28, 2021 (structure data deposition date) |
Authors | Cui, H. / Carlson, A.S. / Schleiff, M.A. / Divakaran, A. / Johnson, J.A. / Buchholz, C.R. / Zahid, H. / Vail, N.R. / Shi, K. / Aihara, H. ...Cui, H. / Carlson, A.S. / Schleiff, M.A. / Divakaran, A. / Johnson, J.A. / Buchholz, C.R. / Zahid, H. / Vail, N.R. / Shi, K. / Aihara, H. / Harki, D.A. / Miller, G.P. / Topczewski, J.J. / Pomerantz, W.C.K. |
External links | J. Med. Chem. / PubMed:34236185 |
Methods | X-ray diffraction |
Resolution | 1.2 - 1.32 Å |
Structure data | PDB-7mlq: PDB-7mlr: PDB-7mls: |
Chemicals | ChemComp-EDO: ChemComp-ZHV: ChemComp-CL: ChemComp-HOH: ChemComp-ZHS: ChemComp-NA: ChemComp-ZHM: |
Source |
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Keywords | GENE REGULATION/INHIBITOR / BRD4 / GENE REGULATION / GENE REGULATION-INHIBITOR complex |