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TitleSulfatides are endogenous ligands for the TLR4-MD-2 complex.
Journal, issue, pagesProc. Natl. Acad. Sci. USA, Vol. 118, Year 2021
Publish dateApr 28, 2021 (structure data deposition date)
AuthorsSu, L. / Athamna, M. / Wang, Y. / Wang, J. / Freudenberg, M. / Yue, T. / Moresco, E.M.Y. / He, H. / Zor, T. / Beutler, B.
External linksProc. Natl. Acad. Sci. USA / PubMed:34290146
MethodsX-ray diffraction
Resolution2.104 Å
Structure data

PDB-7mlm:
Crystal structure of mouse TLR4/MD-2 in complex with sulfatides
Method: X-RAY DIFFRACTION / Resolution: 2.104 Å

Chemicals

ChemComp-NAG:
2-acetamido-2-deoxy-beta-D-glucopyranose

ChemComp-ZKM:
N-[(1S,2R,3E)-2-hydroxy-1-{[(3-O-sulfo-beta-D-galactopyranosyl)oxy]methyl}heptadec-3-en-1-yl]-hexadecanamide

ChemComp-HOH:
WATER

Source
  • mus musculus (house mouse)
  • eptatretus burgeri (inshore hagfish)
KeywordsIMMUNE SYSTEM / Innate immunity / endogenous ligands / Toll-like receptors

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