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TitleCross-HLA targeting of intracellular oncoproteins with peptide-centric CARs.
Journal, issue, pagesNature, Vol. 599, Page 477-484, Year 2021
Publish dateApr 19, 2021 (structure data deposition date)
AuthorsYarmarkovich, M. / Marshall, Q.F. / Warrington, J.M. / Premaratne, R. / Farrel, A. / Groff, D. / Li, W. / di Marco, M. / Runbeck, E. / Truong, H. ...Yarmarkovich, M. / Marshall, Q.F. / Warrington, J.M. / Premaratne, R. / Farrel, A. / Groff, D. / Li, W. / di Marco, M. / Runbeck, E. / Truong, H. / Toor, J.S. / Tripathi, S. / Nguyen, S. / Shen, H. / Noel, T. / Church, N.L. / Weiner, A. / Kendsersky, N. / Martinez, D. / Weisberg, R. / Christie, M. / Eisenlohr, L. / Bosse, K.R. / Dimitrov, D.S. / Stevanovic, S. / Sgourakis, N.G. / Kiefel, B.R. / Maris, J.M.
External linksNature / PubMed:34732890
MethodsX-ray diffraction
Resolution1.6 - 1.95 Å
Structure data

PDB-7mj6:
HLA-A*02:01 bound to Neuroblastoma Derived IGFBPL1 peptide
Method: X-RAY DIFFRACTION / Resolution: 1.95 Å

PDB-7mj7:
HLA-A*02:01 bound to Neuroblastoma Derived IGFBPL1 peptide
Method: X-RAY DIFFRACTION / Resolution: 1.6 Å

PDB-7mj8:
HLA-A*02:01 bound to Neuroblastoma Derived IGFBPL1 peptide
Method: X-RAY DIFFRACTION / Resolution: 1.79 Å

PDB-7mj9:
HLA-A*02:01 bound to Neuroblastoma Derived mutant IGFBPL1 peptide
Method: X-RAY DIFFRACTION / Resolution: 1.75 Å

PDB-7mja:
HLA-A*24:02 bound to Neuroblastoma derived PHOX2B peptide
Method: X-RAY DIFFRACTION / Resolution: 1.69 Å

Chemicals

ChemComp-GOL:
GLYCEROL

ChemComp-HOH:
WATER

Source
  • homo sapiens (human)
KeywordsIMMUNE SYSTEM / NEUROBLASTOMA TUMOR ANTIGEN / IGFBPL1 / HUMAN MAJOR HISTOCOMPATIBILITY COMPLEX CLASS I / MHC-I / COMPLEX / LYMPHOMA KINASE-DERIVED NEUROBLASTOMA TUMOR ANTIGEN / PHOX2B

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