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TitleBinding and Action of Triphenylphosphonium Analog of Chloramphenicol upon the Bacterial Ribosome.
Journal, issue, pagesAntibiotics, Vol. 10, Year 2021
Publish dateApr 3, 2021 (structure data deposition date)
AuthorsChen, C.W. / Pavlova, J.A. / Lukianov, D.A. / Tereshchenkov, A.G. / Makarov, G.I. / Khairullina, Z.Z. / Tashlitsky, V.N. / Paleskava, A. / Konevega, A.L. / Bogdanov, A.A. ...Chen, C.W. / Pavlova, J.A. / Lukianov, D.A. / Tereshchenkov, A.G. / Makarov, G.I. / Khairullina, Z.Z. / Tashlitsky, V.N. / Paleskava, A. / Konevega, A.L. / Bogdanov, A.A. / Osterman, I.A. / Sumbatyan, N.V. / Polikanov, Y.S.
External linksAntibiotics / PubMed:33916420
MethodsX-ray diffraction
Resolution2.8 Å
Structure data

PDB-7md7:
Crystal structure of the Thermus thermophilus 70S ribosome in complex with triphenylphosphonium analog of chloramphenicol CAM-C4-TPP and protein Y (YfiA) at 2.80A resolution
Method: X-RAY DIFFRACTION / Resolution: 2.8 Å

Chemicals

ChemComp-MG:
Unknown entry

ChemComp-YXM:
N-[(1R,2R)-1,3-dihydroxy-1-(4-nitrophenyl)propan-2-yl]-5-(triphenyl-lambda~5~-phosphanyl)pentanamide

ChemComp-MPD:
(4S)-2-METHYL-2,4-PENTANEDIOL / precipitant*YM

ChemComp-ARG:
ARGININE

ChemComp-ZN:
Unknown entry

ChemComp-SF4:
IRON/SULFUR CLUSTER

ChemComp-HOH:
WATER

Source
  • escherichia coli (strain k12) (bacteria)
  • thermus thermophilus hb8 (bacteria)
  • thermus thermophilus (strain hb8 / atcc 27634 / dsm 579) (bacteria)
KeywordsRIBOSOME / chloramphenicol / antibiotic / 70S ribosome / translation inhibitor / peptidyl transferase center / nascent peptide exit tunnel

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