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TitlePotent and specific antibiotic combination therapy against Clostridioides difficile.
Journal, issue, pagesNat. Chem. Biol., Vol. 20, Page 924-933, Year 2024
Publish dateFeb 2, 2021 (structure data deposition date)
AuthorsChioti, V.T. / McWhorter, K.L. / Blue, T.C. / Li, Y. / Xu, F. / Jeffrey, P.D. / Davis, K.M. / Seyedsayamdost, M.R.
External linksNat. Chem. Biol. / PubMed:38942968
MethodsX-ray diffraction
Resolution0.95 Å
Structure data

PDB-7lkc:
Crystal Structure of Keratinimicin A
Method: X-RAY DIFFRACTION / Resolution: 0.95 Å

PDB-7ltb:
Crystal Structure of Keratinicyclin B
Method: X-RAY DIFFRACTION / Resolution: 0.95 Å

Chemicals

ChemComp-MAN:
alpha-D-mannopyranose

ChemComp-YBJ:
(2~{S},4~{S},5~{R},6~{S})-4-azanyl-5-methoxy-6-methyl-oxan-2-ol

ChemComp-FMT:
FORMIC ACID

ChemComp-CL:
Unknown entry

ChemComp-HOH:
WATER

Source
  • amycolatopsis keratiniphila (bacteria)
KeywordsANTIBIOTIC / Glycopeptide / ACTINOMYCETE / BIOSYNTHESIS

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