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Structure paper

TitleAcute pharmacological degradation of Helios destabilizes regulatory T cells.
Journal, issue, pagesNat. Chem. Biol., Vol. 17, Page 711-717, Year 2021
Publish dateFeb 12, 2021 (structure data deposition date)
AuthorsWang, E.S. / Verano, A.L. / Nowak, R.P. / Yuan, J.C. / Donovan, K.A. / Eleuteri, N.A. / Yue, H. / Ngo, K.H. / Lizotte, P.H. / Gokhale, P.C. ...Wang, E.S. / Verano, A.L. / Nowak, R.P. / Yuan, J.C. / Donovan, K.A. / Eleuteri, N.A. / Yue, H. / Ngo, K.H. / Lizotte, P.H. / Gokhale, P.C. / Gray, N.S. / Fischer, E.S.
External linksNat. Chem. Biol. / PubMed:34035522
MethodsX-ray diffraction
Resolution3.78 Å
Structure data

PDB-7lps:
Crystal structure of DDB1-CRBN-ALV1 complex bound to Helios (IKZF2 ZF2)
Method: X-RAY DIFFRACTION / Resolution: 3.78 Å

Chemicals

ChemComp-ZN:
Unknown entry

ChemComp-RN9:
3-[3-[[1-[(3~{S})-2,6-bis(oxidanylidene)piperidin-3-yl]-2,5-bis(oxidanylidene)pyrrol-3-yl]amino]phenyl]-~{N}-(3-chloranyl-4-methyl-phenyl)propanamide

Source
  • homo sapiens (human)
KeywordsLIGASE / CRBN / DDB1 / IKZF2 / ALV / Degradation / E3 ligase

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