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TitleCrystal structure of the second bromodomain (BD2) of human TAF1 bound to ZS1-580
Journal, issue, pagesTo Be Published
Publish dateJan 7, 2021 (structure data deposition date)
AuthorsKarim, M.R. / Schonbrunn, E.
External linksSearch PubMed
MethodsX-ray diffraction
Resolution1.9 Å
Structure data

PDB-7lb3:
Crystal structure of the second bromodomain (BD2) of human TAF1 bound to ZS1-580
Method: X-RAY DIFFRACTION / Resolution: 1.9 Å

Chemicals

ChemComp-XXS:
4-{4-[(3R)-3-methylmorpholin-4-yl]-6-[1-(S-methylsulfonimidoyl)cyclopropyl]pyrimidin-2-yl}-1H-indazole

ChemComp-EDO:
1,2-ETHANEDIOL

ChemComp-HOH:
WATER

Source
  • homo sapiens (human)
KeywordsGENE REGULATION / Bromodomain / TAF1 / non-BET / BET / kinase inhibitor / ATR / dual BRD-kinase / transferase

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