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-Structure paper
Title | Discovery of Quinoxaline-Based P1-P3 Macrocyclic NS3/4A Protease Inhibitors with Potent Activity against Drug-Resistant Hepatitis C Virus Variants. |
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Journal, issue, pages | J. Med. Chem., Vol. 64, Page 11972-11989, Year 2021 |
Publish date | Dec 29, 2020 (structure data deposition date) |
![]() | Nageswara Rao, D. / Zephyr, J. / Henes, M. / Chan, E.T. / Matthew, A.N. / Hedger, A.K. / Conway, H.L. / Saeed, M. / Newton, A. / Petropoulos, C.J. ...Nageswara Rao, D. / Zephyr, J. / Henes, M. / Chan, E.T. / Matthew, A.N. / Hedger, A.K. / Conway, H.L. / Saeed, M. / Newton, A. / Petropoulos, C.J. / Huang, W. / Kurt Yilmaz, N. / Schiffer, C.A. / Ali, A. |
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Methods | X-ray diffraction |
Resolution | 1.58 - 1.88 Å |
Structure data | ![]() PDB-7l7l: ![]() PDB-7l7n: ![]() PDB-7l7o: ![]() PDB-7l7p: |
Chemicals | ![]() ChemComp-ZN: ![]() ChemComp-EDO: ![]() ChemComp-XSS: ![]() ChemComp-HOH: ![]() ChemComp-XSV: ![]() ChemComp-SO4: ![]() ChemComp-XSY: ![]() ChemComp-XT4: |
Source |
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![]() | HYDROLASE/INHIBITOR / NS3/4a Protease / Hepatitis C virus / Drug Resistance / Protease inhibitor / HYDROLASE-HYDROLASE Inhibitor complex / HYDROLASE / HYDROLASE-INHIBITOR complex |