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TitleA Biparatopic Antibody-Drug Conjugate to Treat MET-Expressing Cancers, Including Those that Are Unresponsive to MET Pathway Blockade.
Journal, issue, pagesMol. Cancer Ther., Vol. 20, Page 1966-1976, Year 2021
Publish dateDec 11, 2020 (structure data deposition date)
AuthorsDaSilva, J.O. / Yang, K. / Surriga, O. / Nittoli, T. / Kunz, A. / Franklin, M.C. / Delfino, F.J. / Mao, S. / Zhao, F. / Giurleo, J.T. ...DaSilva, J.O. / Yang, K. / Surriga, O. / Nittoli, T. / Kunz, A. / Franklin, M.C. / Delfino, F.J. / Mao, S. / Zhao, F. / Giurleo, J.T. / Kelly, M.P. / Makonnen, S. / Hickey, C. / Krueger, P. / Foster, R. / Chen, Z. / Retter, M.W. / Slim, R. / Young, T.M. / Olson, W.C. / Thurston, G. / Daly, C.
External linksMol. Cancer Ther. / PubMed:34315762
MethodsX-ray diffraction
Resolution2.21 Å
Structure data

PDB-7l05:
Complex of novel maytansinoid M24 bound to T2R-TTL (two tubulin alpha/beta heterodimers, RB3 stathmin-like domain, and tubulin tyrosine ligase)
Method: X-RAY DIFFRACTION / Resolution: 2.21 Å

Chemicals

ChemComp-GTP:
GUANOSINE-5'-TRIPHOSPHATE / GTP, energy-carrying molecule*YM

ChemComp-MG:
Unknown entry

ChemComp-CA:
Unknown entry

ChemComp-CL:
Unknown entry

ChemComp-EDO:
1,2-ETHANEDIOL

ChemComp-GDP:
GUANOSINE-5'-DIPHOSPHATE / GDP, energy-carrying molecule*YM

ChemComp-MES:
2-(N-MORPHOLINO)-ETHANESULFONIC ACID / pH buffer*YM

ChemComp-XQ4:
(1S,2R,3S,5S,6S,16E,18E,20R,21S)-11-chloro-21-hydroxy-12,20-dimethoxy-2,5,9,16-tetramethyl-8,23-dioxo-4,24-dioxa-9,22-diazatetracyclo[19.3.1.1~10,14~.0~3,5~]hexacosa-10(26),11,13,16,18-pentaen-6-yl (2S)-2-{methyl[3-(methylamino)propanoyl]amino}propanoate (non-preferred name)

ChemComp-ACP:
PHOSPHOMETHYLPHOSPHONIC ACID ADENYLATE ESTER / AMP-PCP, energy-carrying molecule analogue*YM

ChemComp-HOH:
WATER

Source
  • rattus norvegicus (Norway rat)
  • gallus gallus (chicken)
  • sus scrofa (pig)
KeywordsSTRUCTURAL PROTEIN / maytansinoid / tubulin / antibody-drug conjugate

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