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Structure paper

TitleStructure-Guided Development of Small-Molecule PRC2 Inhibitors Targeting EZH2-EED Interaction.
Journal, issue, pagesJ. Med. Chem., Vol. 64, Page 8194-8207, Year 2021
Publish dateDec 4, 2020 (structure data deposition date)
AuthorsDu, D. / Xu, D. / Zhu, L. / Stazi, G. / Zwergel, C. / Liu, Y. / Luo, Z. / Li, Y. / Zhang, Y. / Zhu, K. ...Du, D. / Xu, D. / Zhu, L. / Stazi, G. / Zwergel, C. / Liu, Y. / Luo, Z. / Li, Y. / Zhang, Y. / Zhu, K. / Ding, Y. / Liu, J. / Fan, S. / Zhao, K. / Zhang, N. / Kong, X. / Jiang, H. / Chen, K. / Valente, S. / Min, J. / Duan, W. / Luo, C.
External linksJ. Med. Chem. / PubMed:34077206
MethodsX-ray diffraction
Resolution2.15 Å
Structure data

PDB-7kxt:
Crystal structure of human EED
Method: X-RAY DIFFRACTION / Resolution: 2.15 Å

Chemicals

ChemComp-XB7:
1-[(4-fluorophenyl)methyl]-N-{1-[2-(4-methoxyphenyl)ethyl]piperidin-4-yl}-1H-benzimidazol-2-amine

ChemComp-UNX:
Unknown entry

ChemComp-HOH:
WATER

Source
  • homo sapiens (human)
KeywordsGENE REGULATION / EED / WD40 / Structural Genomics / Structural Genomics Consortium / SGC

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