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TitlePotency boost of a Mycobacterium tuberculosis dihydrofolate reductase inhibitor by multienzyme F 420 H 2 -dependent reduction.
Journal, issue, pagesProc. Natl. Acad. Sci. USA, Vol. 118, Year 2021
Publish dateOct 29, 2020 (structure data deposition date)
AuthorsAragaw, W.W. / Lee, B.M. / Yang, X. / Zimmerman, M.D. / Gengenbacher, M. / Dartois, V. / Chui, W.K. / Jackson, C.J. / Dick, T.
External linksProc. Natl. Acad. Sci. USA / PubMed:34161270
MethodsX-ray diffraction
Resolution2.469 Å
Structure data

PDB-7kl8:
Structure of F420 binding protein Rv1558 from Mycobacterium tuberculosis with F420 bound
Method: X-RAY DIFFRACTION / Resolution: 2.469 Å

Chemicals

ChemComp-6J4:
COENZYME F420-3

ChemComp-SO4:
SULFATE ION

ChemComp-F42:
COENZYME F420

ChemComp-HOH:
WATER

Source
  • mycobacterium tuberculosis (bacteria)
KeywordsOXIDOREDUCTASE / F420 / FDOR

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