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TitleStructural recognition of the MYC promoter G-quadruplex by a quinoline derivative: insights into molecular targeting of parallel G-quadruplexes.
Journal, issue, pagesNucleic Acids Res., Vol. 49, Page 5905-5915, Year 2021
Publish dateOct 3, 2020 (structure data deposition date)
AuthorsDickerhoff, J. / Dai, J. / Yang, D.
External linksNucleic Acids Res. / PubMed:33978746
MethodsNMR (solution)
Structure data

PDB-7kbv:
Solution structure of the major MYC promoter G-quadruplex with a wild-type flanking sequence
Method: SOLUTION NMR

PDB-7kbw:
Solution structure of the major MYC promoter G-quadruplex with a wild-type flanking in complex with NSC85697, a quinoline derivative
Method: SOLUTION NMR

PDB-7kbx:
Solution structure of the major MYC promoter G-quadruplex in complex with NSC85697, a quinoline derivative
Method: SOLUTION NMR

Chemicals

ChemComp-WAM:
2-[(~{E})-2-(3-methoxy-4-oxidanyl-phenyl)ethenyl]-1-methyl-quinoline-4-carboxamide

Source
  • homo sapiens (human)
KeywordsDNA / G-QUADRUPLEX DNA / DRUG-DNA COMPLEX

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