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-Structure paper
Title | Fungal-Selective Resorcylate Aminopyrazole Hsp90 Inhibitors: Optimization of Whole-Cell Anticryptococcal Activity and Insights into the Structural Origins of Cryptococcal Selectivity. |
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Journal, issue, pages | J. Med. Chem., Vol. 64, Page 1139-1169, Year 2021 |
Publish date | Sep 29, 2020 (structure data deposition date) |
Authors | Marcyk, P.T. / LeBlanc, E.V. / Kuntz, D.A. / Xue, A. / Ortiz, F. / Trilles, R. / Bengtson, S. / Kenney, T.M.G. / Huang, D.S. / Robbins, N. ...Marcyk, P.T. / LeBlanc, E.V. / Kuntz, D.A. / Xue, A. / Ortiz, F. / Trilles, R. / Bengtson, S. / Kenney, T.M.G. / Huang, D.S. / Robbins, N. / Williams, N.S. / Krysan, D.J. / Prive, G.G. / Whitesell, L. / Cowen, L.E. / Brown, L.E. |
External links | J. Med. Chem. / PubMed:33444025 |
Methods | X-ray diffraction |
Resolution | 1.91 - 3.21 Å |
Structure data | PDB-7k9r: PDB-7k9s: PDB-7k9u: PDB-7k9v: PDB-7k9w: |
Chemicals | ChemComp-CL: ChemComp-HOH: ChemComp-2GJ: ChemComp-W8Y: ChemComp-W8V: ChemComp-BEN: ChemComp-GOL: ChemComp-W8S: |
Source |
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Keywords | CHAPERONE / Crytococcus neoformans / HSP90 ATP-binding / Cryptococcus / HSP90 / ATP-binding / Inhibitor |