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-Structure paper
Title | MetAP2 inhibition modifies hemoglobin S to delay polymerization and improves blood flow in sickle cell disease. |
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Journal, issue, pages | Blood Adv, Vol. 5, Page 1388-1402, Year 2021 |
Publish date | Sep 15, 2020 (structure data deposition date) |
Authors | Demers, M. / Sturtevant, S. / Guertin, K.R. / Gupta, D. / Desai, K. / Vieira, B.F. / Li, W. / Hicks, A. / Ismail, A. / Goncalves, B.P. ...Demers, M. / Sturtevant, S. / Guertin, K.R. / Gupta, D. / Desai, K. / Vieira, B.F. / Li, W. / Hicks, A. / Ismail, A. / Goncalves, B.P. / Di Caprio, G. / Schonbrun, E. / Hansen, S. / Musayev, F.N. / Safo, M.K. / Wood, D.K. / Higgins, J.M. / Light, D.R. |
External links | Blood Adv / PubMed:33661300 |
Methods | X-ray diffraction |
Resolution | 2.5 Å |
Structure data | PDB-7k4m: |
Chemicals | ChemComp-CMO: ChemComp-HEM: ChemComp-HOH: |
Source |
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Keywords | OXYGEN TRANSPORT / HEMOGLOBIN S / INHIBITOR / ANTISICKLING |