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TitleRational design of a new antibiotic class for drug-resistant infections.
Journal, issue, pagesNature, Vol. 597, Page 698-702, Year 2021
Publish dateAug 25, 2020 (structure data deposition date)
AuthorsDurand-Reville, T.F. / Miller, A.A. / O'Donnell, J.P. / Wu, X. / Sylvester, M.A. / Guler, S. / Iyer, R. / Shapiro, A.B. / Carter, N.M. / Velez-Vega, C. ...Durand-Reville, T.F. / Miller, A.A. / O'Donnell, J.P. / Wu, X. / Sylvester, M.A. / Guler, S. / Iyer, R. / Shapiro, A.B. / Carter, N.M. / Velez-Vega, C. / Moussa, S.H. / McLeod, S.M. / Chen, A. / Tanudra, A.M. / Zhang, J. / Comita-Prevoir, J. / Romero, J.A. / Huynh, H. / Ferguson, A.D. / Horanyi, P.S. / Mayclin, S.J. / Heine, H.S. / Drusano, G.L. / Cummings, J.E. / Slayden, R.A. / Tommasi, R.A.
External linksNature / PubMed:34526714
MethodsX-ray diffraction
Resolution2.2 Å
Structure data

PDB-7jwl:
Crystal Structure of Pseudomonas aeruginosa Penicillin Binding Protein 3 (PAE-PBP3) bound to ETX0462
Method: X-RAY DIFFRACTION / Resolution: 2.2 Å

Chemicals

ChemComp-CL:
Unknown entry

ChemComp-VMM:
ETX0462 (Bound form)

ChemComp-HOH:
WATER

Source
  • pseudomonas aeruginosa (bacteria)
KeywordsANTIBIOTIC / PSEUDOMONAS AERUGINOSA / PBP3 / ETX0462

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