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-Structure paper
Title | Discovery of a phenylpyrazole amide ROCK inhibitor as a tool molecule for in vivo studies. |
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Journal, issue, pages | Bioorg. Med. Chem. Lett., Vol. 30, Page 127495-127495, Year 2020 |
Publish date | Aug 7, 2020 (structure data deposition date) |
![]() | Hu, Z. / Wang, C. / Glunz, P.W. / Li, J. / Cheadle, N.L. / Chen, A.Y. / Chen, X.Q. / Myers, J.E. / Guarino, V.R. / Rose, A. ...Hu, Z. / Wang, C. / Glunz, P.W. / Li, J. / Cheadle, N.L. / Chen, A.Y. / Chen, X.Q. / Myers, J.E. / Guarino, V.R. / Rose, A. / Sack, J.S. / Sitkoff, D. / Taylor, D.S. / Xu, S. / Yan, C. / Zhang, H. / Zhang, L. / Hennan, J. / Adam, L.P. / Wexler, R.R. / Quan, M.L. |
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Methods | X-ray diffraction |
Resolution | 2.586 - 3.318 Å |
Structure data | ![]() PDB-7jou: ![]() PDB-7jov: |
Chemicals | ![]() ChemComp-VFS: ![]() ChemComp-HOH: ![]() ChemComp-MES: ![]() ChemComp-CL: |
Source |
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![]() | TRANSFERASE/TRANSFERASE INHIBITOR / ROCK1 / KINASE / TRANSFERASE / TRANSFERASE-TRANSFERASE INHIBITOR COMPLEX |