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TitleIdentification of 5H-chromeno[3,4-c]pyridine and 6H-isochromeno[3,4-c]pyridine derivatives as potent and selective dual ROCK inhibitors.
Journal, issue, pagesBioorg. Med. Chem. Lett., Vol. 30, Page 127474-127474, Year 2020
Publish dateAug 5, 2020 (structure data deposition date)
AuthorsHu, Z. / Wang, C. / Sitkoff, D. / Cheadle, N.L. / Xu, S. / Muckelbauer, J.K. / Adam, L.P. / Wexler, R.R. / Quan, M.L.
External linksBioorg. Med. Chem. Lett. / PubMed:32805407
MethodsX-ray diffraction
Resolution2.214 Å
Structure data

PDB-7jnt:
CRYSTAL STRUCTURE OF RHO-ASSOCIATED PROTEIN KINASE 2 (ROCK2) IN COMPLEX WITH A POTENT AND SELECTIVE DUAL ROCK INHIBITOR
Method: X-RAY DIFFRACTION / Resolution: 2.214 Å

Chemicals

ChemComp-VFA:
N-[(3-methoxyphenyl)methyl]-5H-[1]benzopyrano[3,4-c]pyridine-8-carboxamide

ChemComp-MES:
2-(N-MORPHOLINO)-ETHANESULFONIC ACID / pH buffer*YM

ChemComp-CL:
Unknown entry

ChemComp-HOH:
WATER

Source
  • homo sapiens (human)
KeywordsTRANSFERASE / ROCK 2 / KINASE / TRANSFERASE-TRANSFERASE INHIBIT COMPLEX / TRANSFERASE-TRANSFERASE INHIBITOR complex

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