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TitleStructure of the activated ROQ1 resistosome directly recognizing the pathogen effector XopQ.
Journal, issue, pagesScience, Vol. 370, Issue 6521, Year 2020
Publish dateDec 4, 2020
AuthorsRaoul Martin / Tiancong Qi / Haibo Zhang / Furong Liu / Miles King / Claire Toth / Eva Nogales / Brian J Staskawicz /
PubMed AbstractPlants and animals detect pathogen infection using intracellular nucleotide-binding leucine-rich repeat receptors (NLRs) that directly or indirectly recognize pathogen effectors and activate an ...Plants and animals detect pathogen infection using intracellular nucleotide-binding leucine-rich repeat receptors (NLRs) that directly or indirectly recognize pathogen effectors and activate an immune response. How effector sensing triggers NLR activation remains poorly understood. Here we describe the 3.8-angstrom-resolution cryo-electron microscopy structure of the activated ROQ1 (recognition of XopQ 1), an NLR native to with a Toll-like interleukin-1 receptor (TIR) domain bound to the effector XopQ ( outer protein Q). ROQ1 directly binds to both the predicted active site and surface residues of XopQ while forming a tetrameric resistosome that brings together the TIR domains for downstream immune signaling. Our results suggest a mechanism for the direct recognition of effectors by NLRs leading to the oligomerization-dependent activation of a plant resistosome and signaling by the TIR domain.
External linksScience / PubMed:33273074 / PubMed Central
MethodsEM (single particle)
Resolution3.8 - 4.6 Å
Structure data

22380

7jlu

EMDB-22380, PDB-7jlu:
Structure of the activated Roq1 resistosome directly recognizing the pathogen effector XopQ
Method: EM (single particle) / Resolution: 3.8 Å

22381

7jlv

EMDB-22381, PDB-7jlv:
Structure of the activated Roq1 resistosome directly recognizing the pathogen effector XopQ
Method: EM (single particle) / Resolution: 3.8 Å

22383

7jlx

EMDB-22383, PDB-7jlx:
Structure of the activated Roq1 resistosome directly recognizing the pathogen effector XopQ (TIR domains)
Method: EM (single particle) / Resolution: 4.6 Å

Chemicals

ChemComp-CA:
Unknown entry

ChemComp-ATP:
ADENOSINE-5'-TRIPHOSPHATE / ATP, energy-carrying molecule*YM

ChemComp-MG:
Unknown entry

Source
  • nicotiana benthamiana (plant)
  • xanthomonas euvesicatoria (bacteria)
KeywordsIMMUNE SYSTEM / Resistosome / Plant Immunity / Effector / LRR / TIR / NB-ARC / PL.

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