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-Structure paper
Title | Chemoproteomic discovery of a covalent allosteric inhibitor of WRN helicase. |
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Journal, issue, pages | Nature, Vol. 629, Page 435-442, Year 2024 |
Publish date | Oct 19, 2023 (structure data deposition date) |
Authors | Baltgalvis, K.A. / Lamb, K.N. / Symons, K.T. / Wu, C.C. / Hoffman, M.A. / Snead, A.N. / Song, X. / Glaza, T. / Kikuchi, S. / Green, J.C. ...Baltgalvis, K.A. / Lamb, K.N. / Symons, K.T. / Wu, C.C. / Hoffman, M.A. / Snead, A.N. / Song, X. / Glaza, T. / Kikuchi, S. / Green, J.C. / Rogness, D.C. / Lam, B. / Rodriguez-Aguirre, M.E. / Woody, D.R. / Eissler, C.L. / Rodiles, S. / Negron, S.M. / Bernard, S.M. / Tran, E. / Pollock, J. / Tabatabaei, A. / Contreras, V. / Williams, H.N. / Pastuszka, M.K. / Sigler, J.J. / Pettazzoni, P. / Rudolph, M.G. / Classen, M. / Brugger, D. / Claiborne, C. / Plancher, J.M. / Cuartas, I. / Seoane, J. / Burgess, L.E. / Abraham, R.T. / Weinstein, D.S. / Simon, G.M. / Patricelli, M.P. / Kinsella, T.M. |
External links | Nature / PubMed:38658751 |
Methods | X-ray diffraction |
Resolution | 1.54 - 2.21 Å |
Structure data | PDB-7gqs: PDB-7gqt: PDB-7gqu: |
Chemicals | ChemComp-ADP: ChemComp-CD: ChemComp-EDO: ChemComp-CL: ChemComp-HOH: ChemComp-ZN: ChemComp-ATP: ChemComp-MG:
ChemComp-X1L: ChemComp-GOL: ChemComp-NA: |
Source |
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Keywords | HYDROLASE / DNA HELICASE / WERNER SYNDROME / RecQ protein-like 2 / ATP-dependent helicase / Bifunctional 3'-5' exonuclease/ATP-dependent helicase / WRN Werner syndrome protein / RecQ-like type 3 / HELICASE / DNA REPAIR |