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Structure paper

TitleATP mimetics targeting prolyl-tRNA synthetases as a new avenue for antimalarial drug development
Journal, issue, pagesIscience, Vol. 27, Year 2024
Publish dateJul 4, 2021 (structure data deposition date)
AuthorsMishra, S. / Malhotra, N. / Laleu, B. / Chakraborti, S. / Yogavel, M. / Sharma, A.
External linksIscience / Search PubMed
MethodsX-ray diffraction
Resolution2.394 - 2.577 Å
Structure data

PDB-7f96:
Plasmodium falciparum Prolyl-tRNA Synthetase (PfPRS) in Complex with L-proline and compound L95
Method: X-RAY DIFFRACTION / Resolution: 2.577 Å

PDB-7f97:
Plasmodium falciparum Prolyl-tRNA Synthetase (PfPRS) in Complex with L-proline and compound L97
Method: X-RAY DIFFRACTION / Resolution: 2.394 Å

Chemicals

ChemComp-JE6:
~{N}-[4-[(3~{S})-3-cyano-3-cyclopropyl-2-oxidanylidene-pyrrolidin-1-yl]-6-methyl-pyridin-2-yl]-2-phenyl-ethanamide

ChemComp-PRO:
PROLINE

ChemComp-HOH:
WATER

ChemComp-1XK:
4-[(3S)-3-cyclopropyl-3-(hydroxymethyl)-2-oxidanylidene-pyrrolidin-1-yl]-N-[[3-fluoranyl-5-(1-methylpyrazol-4-yl)phenyl]methyl]-6-methyl-pyridine-2-carboxamide

ChemComp-BU1:
1,4-BUTANEDIOL

ChemComp-CL:
Unknown entry

ChemComp-HEZ:
HEXANE-1,6-DIOL

Source
  • plasmodium falciparum 3d7 (eukaryote)
KeywordsLIGASE / PROTEIN TRANSLATION / MALARIA / INHIBITOR / PRS / LIGASE/LIGASE INHIBITOR / LIGASE-LIGASE INHIBITOR complex

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