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TitleA novel partially open state of SHP2 points to a "multiple gear" regulation mechanism.
Journal, issue, pagesJ. Biol. Chem., Vol. 296, Page 100538-100538, Year 2021
Publish dateApr 14, 2021 (structure data deposition date)
AuthorsTao, Y. / Xie, J. / Zhong, Q. / Wang, Y. / Zhang, S. / Luo, F. / Wen, F. / Zhao, J. / Sun, X. / Long, H. ...Tao, Y. / Xie, J. / Zhong, Q. / Wang, Y. / Zhang, S. / Luo, F. / Wen, F. / Zhao, J. / Sun, X. / Long, H. / Ma, J. / Zhang, Q. / Long, J. / Fang, X. / Lu, Y. / Li, D. / Li, M. / Zhu, J. / Sun, B. / Li, G. / Diao, J. / Liu, C.
External linksJ. Biol. Chem. / PubMed:33722610
MethodsX-ray diffraction
Resolution3 Å
Structure data

PDB-7emn:
The atomic structure of SHP2 E76A mutant
Method: X-RAY DIFFRACTION / Resolution: 3 Å

Chemicals

ChemComp-HOH:
WATER

Source
  • homo sapiens (human)
KeywordsHYDROLASE / Phosphatase

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