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TitleRepurposing antiparasitic antimonials to noncovalently rescue temperature-sensitive p53 mutations.
Journal, issue, pagesCell Rep, Vol. 39, Page 110622-110622, Year 2022
Publish dateMar 8, 2021 (structure data deposition date)
AuthorsTang, Y. / Song, H. / Wang, Z. / Xiao, S. / Xiang, X. / Zhan, H. / Wu, L. / Wu, J. / Xing, Y. / Tan, Y. ...Tang, Y. / Song, H. / Wang, Z. / Xiao, S. / Xiang, X. / Zhan, H. / Wu, L. / Wu, J. / Xing, Y. / Tan, Y. / Liang, Y. / Yan, N. / Li, Y. / Li, J. / Zheng, D. / Jia, Y. / Chen, Z. / Zhang, Q. / Zhang, J. / Zeng, H. / Tao, W. / Liu, F. / Wu, Y. / Lu, M.
External linksCell Rep / PubMed:35417717
MethodsX-ray diffraction
Resolution2.55 Å
Structure data

PDB-7eax:
Crystal complex of p53-V272M and antimony ion
Method: X-RAY DIFFRACTION / Resolution: 2.55 Å

Chemicals

ChemComp-ZN:
Unknown entry

ChemComp-SB:
ANTIMONY (III) ION

ChemComp-HOH:
WATER

Source
  • homo sapiens (human)
KeywordsANTITUMOR PROTEIN / tumor suppressor p53 / structural stabilization

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