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TitleSpatially restricted substrate-binding site of cortisol-synthesizing CYP11B1 limits multiple hydroxylations and hinders aldosterone synthesis.
Journal, issue, pagesCurr Res Struct Biol, Vol. 3, Page 192-205, Year 2021
Publish dateFeb 26, 2021 (structure data deposition date)
AuthorsMukai, K. / Sugimoto, H. / Kamiya, K. / Suzuki, R. / Matsuura, T. / Hishiki, T. / Shimada, H. / Shiro, Y. / Suematsu, M. / Kagawa, N.
External linksCurr Res Struct Biol / PubMed:34485929
MethodsX-ray diffraction
Resolution1.4 Å
Structure data

PDB-7e7f:
Human CYP11B1 mutant in complex with metyrapone
Method: X-RAY DIFFRACTION / Resolution: 1.4 Å

Chemicals

ChemComp-HEM:
PROTOPORPHYRIN IX CONTAINING FE

ChemComp-MYT:
METYRAPONE / medication, inhibitor*YM

ChemComp-CHD:
CHOLIC ACID

ChemComp-GOL:
GLYCEROL

ChemComp-HOH:
WATER

Source
  • homo sapiens (human)
KeywordsOXIDOREDUCTASE / P450

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