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-Structure paper
Title | Lead optimization of 2-hydroxymethyl imidazoles as non-hydroxamate LpxC inhibitors: Discovery of TP0586532. |
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Journal, issue, pages | Bioorg. Med. Chem., Vol. 30, Page 115964-115964, Year 2020 |
Publish date | Nov 4, 2020 (structure data deposition date) |
Authors | Ushiyama, F. / Takashima, H. / Matsuda, Y. / Ogata, Y. / Sasamoto, N. / Kurimoto-Tsuruta, R. / Ueki, K. / Tanaka-Yamamoto, N. / Endo, M. / Mima, M. ...Ushiyama, F. / Takashima, H. / Matsuda, Y. / Ogata, Y. / Sasamoto, N. / Kurimoto-Tsuruta, R. / Ueki, K. / Tanaka-Yamamoto, N. / Endo, M. / Mima, M. / Fujita, K. / Takata, I. / Tsuji, S. / Yamashita, H. / Okumura, H. / Otake, K. / Sugiyama, H. |
External links | Bioorg. Med. Chem. / PubMed:33385955 |
Methods | X-ray diffraction |
Resolution | 1.9 - 2.15 Å |
Structure data | PDB-7del: PDB-7dem: PDB-7den: |
Chemicals | ChemComp-ZN: ChemComp-H4L: ChemComp-HOH: ChemComp-H4O: ChemComp-H4R: |
Source |
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Keywords | HYDROLASE / UDP-3-O-acyl-N-acetylglucosamine deacetylase EnvA / LpxC / Pseudomonas aeruginosa |