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Structure paper

TitleThe high-resolution X-ray structure of vinca-domain inhibitors of microtubules provides a rational approach for drug design.
Journal, issue, pagesFebs Lett., Vol. 595, Page 195-205, Year 2021
Publish dateAug 2, 2020 (structure data deposition date)
AuthorsChengyong, W. / Jinghong, X. / Yanyan, W. / Qing-Jie, X. / Lingling, M. / Yuyan, L. / Hai, C. / Qian, L. / Quan, Z. / Bo, S. / Yuxi, W.
External linksFebs Lett. / PubMed:33220079
MethodsX-ray diffraction
Resolution2.44 - 2.5 Å
Structure data

PDB-7cnm:
YDX in complex with tubulin
Method: X-RAY DIFFRACTION / Resolution: 2.44 Å

PDB-7cnn:
vinorelbine in complex with tubulin
Method: X-RAY DIFFRACTION / Resolution: 2.5 Å

PDB-7cno:
Phomopsin A in complex with tubulin
Method: X-RAY DIFFRACTION / Resolution: 2.5 Å

Chemicals

ChemComp-GTP:
GUANOSINE-5'-TRIPHOSPHATE / GTP, energy-carrying molecule*YM

ChemComp-MG:
Unknown entry

ChemComp-CA:
Unknown entry

ChemComp-GDP:
GUANOSINE-5'-DIPHOSPHATE / GDP, energy-carrying molecule*YM

ChemComp-MES:
2-(N-MORPHOLINO)-ETHANESULFONIC ACID / pH buffer*YM

ChemComp-G70:
(2~{S},4~{S})-4-[[2-[(1~{R},3~{R})-1-acetyloxy-4-methyl-3-[[(2~{S},3~{S})-3-methyl-2-[[(2~{R})-1-methylpiperidin-2-yl]carbonylamino]pentanoyl]amino]pentyl]-1,3-thiazol-4-yl]carbonylamino]-5-cyclohexyl-2-methyl-pentanoic acid

ChemComp-ACP:
PHOSPHOMETHYLPHOSPHONIC ACID ADENYLATE ESTER / AMP-PCP, energy-carrying molecule analogue*YM

ChemComp-HOH:
WATER

ChemComp-CL:
Unknown entry

ChemComp-GDF:
Vinorelbine / medication, chemotherapy*YM

ChemComp-HOS:
Phomopsin A

Source
  • mus musculus (house mouse)
  • gallus gallus (chicken)
  • sus scrofa (pig)
KeywordsCELL CYCLE / YDX / tubulin / protein-drug complex / Vincristinve / Phomopsin A

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