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TitlePHF8-promoted TOPBP1 demethylation drives ATR activation and preserves genome stability.
Journal, issue, pagesSci Adv, Vol. 7, Year 2021
Publish dateJul 29, 2020 (structure data deposition date)
AuthorsMa, S. / Cao, C. / Che, S. / Wang, Y. / Su, D. / Liu, S. / Gong, W. / Liu, L. / Sun, J. / Zhao, J. ...Ma, S. / Cao, C. / Che, S. / Wang, Y. / Su, D. / Liu, S. / Gong, W. / Liu, L. / Sun, J. / Zhao, J. / Wang, Q. / Song, N. / Ge, T. / Guo, Q. / Tian, S. / Chen, C.D. / Zhang, T. / Wang, J. / Ding, X. / Yang, F. / Ying, G. / Yang, J. / Zhang, K. / Zhu, Y. / Yao, Z. / Yang, N. / Shi, L.
External linksSci Adv / PubMed:33952527
MethodsX-ray diffraction
Resolution1.695 Å
Structure data

PDB-7cmz:
Crystal Structure of BRCT7/8 in Complex with the APS Motif of PHF8
Method: X-RAY DIFFRACTION / Resolution: 1.695 Å

Chemicals

ChemComp-K:
Unknown entry

ChemComp-NA:
Unknown entry

ChemComp-HOH:
WATER

Source
  • homo sapiens (human)
KeywordsPROTEIN BINDING/HYDROLASE / TOPBP1 / PROTEIN BINDING-HYDROLASE complex

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