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TitleThe dual pocket binding novel tankyrase inhibitor K-476 enhances the efficacy of immune checkpoint inhibitor by attracting CD8 + T cells to tumors.
Journal, issue, pagesAm J Cancer Res, Vol. 11, Page 264-276, Year 2021
Publish dateJun 22, 2020 (structure data deposition date)
AuthorsKinosada, H. / Okada-Iwasaki, R. / Kunieda, K. / Suzuki-Imaizumi, M. / Takahashi, Y. / Miyagi, H. / Suzuki, M. / Motosawa, K. / Watanabe, M. / Mie, M. ...Kinosada, H. / Okada-Iwasaki, R. / Kunieda, K. / Suzuki-Imaizumi, M. / Takahashi, Y. / Miyagi, H. / Suzuki, M. / Motosawa, K. / Watanabe, M. / Mie, M. / Ishii, T. / Ishida, H. / Saito, J.I. / Nakai, R.
External linksPubMed:33520373
MethodsX-ray diffraction
Resolution1.5 Å
Structure data

PDB-7ce4:
Tankyrase2 catalytic domain in complex with K-476
Method: X-RAY DIFFRACTION / Resolution: 1.5 Å

Chemicals

ChemComp-ZN:
Unknown entry

ChemComp-SO4:
SULFATE ION

ChemComp-KK6:
5-[3-[[1-(6,7-dimethoxyquinazolin-4-yl)piperidin-4-yl]methyl]-2-oxidanylidene-4H-quinazolin-1-yl]-2-fluoranyl-benzenecarbonitrile

ChemComp-PG4:
TETRAETHYLENE GLYCOL / precipitant*YM

ChemComp-HOH:
WATER

Source
  • homo sapiens (human)
KeywordsTRANSFERASE/TRANSFERASE INHIBITOR / TANKYRASE / PARP / ADP-RIBOSYLATION / TRANSFERASE / INHIBITOR / TRANSFERASE-TRANSFERASE INHIBITOR COMPLEX

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