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TitleDiscovery of the natural product 3',4',7,8-tetrahydroxyflavone as a novel and potent selective BRD4 bromodomain 2 inhibitor.
Journal, issue, pagesJ Enzyme Inhib Med Chem, Vol. 36, Page 903-913, Year 2021
Publish dateMay 10, 2020 (structure data deposition date)
AuthorsLi, J. / Zou, W. / Yu, K. / Liu, B. / Liang, W. / Wang, L. / Lu, Y. / Jiang, Z. / Wang, A. / Zhu, J.
External linksJ Enzyme Inhib Med Chem / PubMed:33820450
MethodsX-ray diffraction
Resolution1.3 - 1.73 Å
Structure data

PDB-7c2z:
Bromodomain-containing 4 BD1 in complex with 3',4',7,8-Tetrahydroxyflavone
Method: X-RAY DIFFRACTION / Resolution: 1.3 Å

PDB-7c6p:
Bromodomain-containing 4 BD2 in complex with 3',4',7,8- Tetrahydroxyflavonoid
Method: X-RAY DIFFRACTION / Resolution: 1.73 Å

Chemicals

ChemComp-SQH:
2-[3,4-bis(oxidanyl)phenyl]-7,8-bis(oxidanyl)chromen-4-one

ChemComp-FMT:
FORMIC ACID

ChemComp-HOH:
WATER

Source
  • homo sapiens (human)
KeywordsGENE REGULATION / BRD4 / BD1 / 3' / 4' / 7 / 8- tetrahydroxyflavonoid / Acute myeloid leukemia / c-MYC / BD2

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