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-Structure paper
Title | Discovery of CA-4948, an Orally Bioavailable IRAK4 Inhibitor for Treatment of Hematologic Malignancies. |
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Journal, issue, pages | Acs Med. Chem. Lett., Vol. 11, Page 2374-2381, Year 2020 |
Publish date | May 9, 2020 (structure data deposition date) |
Authors | Gummadi, V.R. / Boruah, A. / Ainan, B.R. / Vare, B.R. / Manda, S. / Gondle, H.P. / Kumar, S.N. / Mukherjee, S. / Gore, S.T. / Krishnamurthy, N.R. ...Gummadi, V.R. / Boruah, A. / Ainan, B.R. / Vare, B.R. / Manda, S. / Gondle, H.P. / Kumar, S.N. / Mukherjee, S. / Gore, S.T. / Krishnamurthy, N.R. / Marappan, S. / Nayak, S.S. / Nellore, K. / Balasubramanian, W.R. / Bhumireddy, A. / Giri, S. / Gopinath, S. / Samiulla, D.S. / Daginakatte, G. / Basavaraju, A. / Chelur, S. / Eswarappa, R. / Belliappa, C. / Subramanya, H.S. / Booher, R.N. / Ramachandra, M. / Samajdar, S. |
External links | Acs Med. Chem. Lett. / PubMed:33335659 |
Methods | X-ray diffraction |
Resolution | 2.44 - 3.2 Å |
Structure data | PDB-7c2v: PDB-7c2w: |
Chemicals | ChemComp-FJ0: ChemComp-HOH: ChemComp-FJ9: |
Source |
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Keywords | TRANSFERASE/TRANSFERASE INHIBITOR / IRAK4 / Inhibitor / CA-4948 / Kinase / CELL CYCLE / TRANSFERASE-TRANSFERASE INHIBITOR complex |